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344041 InSolution™ cFMS Receptor Tyrosine Kinase Inhibitor - Calbiochem

344041
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₂₂N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
344041-1MG Glass bottle 1 mg
Description
Catalogue Number344041
Brand Family Calbiochem®
References
ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
Product Information
FormLiquid
FormulationA 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344036) in DMSO.
Hill FormulaC₂₀H₂₂N₄O₃
Chemical formulaC₂₀H₂₂N₄O₃
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ cFMS Receptor Tyrosine Kinase Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ cFMS Receptor Tyrosine Kinase Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
344041

References

Reference overview
Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-December-2008 JSW
DescriptionA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo.
FormLiquid
FormulationA 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344036) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₂N₄O₃
Structure formulaStructure formula
Purity≥95% by HPLC
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.