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203389 InSolution™Blebbistatin, Racemic - Calbiochem

203389
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₁₆N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
203389-5MG Plastic ampoule 5 mg
Description
Catalogue Number203389
Brand Family Calbiochem®
References
ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
Hill FormulaC₁₈H₁₆N₂O₂
Chemical formulaC₁₈H₁₆N₂O₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™Blebbistatin, Racemic, is a 50 mM in 90% DMSO. A cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis.
Biological Information
Primary TargetATPase
Primary Target IC<sub>50</sub><100 µM inhibiting the ATPase and gliding motility of human platelets
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™Blebbistatin, Racemic - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™Blebbistatin, Racemic - Calbiochem Certificates of Analysis

TitleLot Number
203389

References

Reference overview
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-May-2008 RFH
DescriptionA cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
FormLiquid
FormulationA 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₆N₂O₂
Structure formulaStructure formula
Purity≥97% by HPLC
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.