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119113 Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem

119113
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₄H₁₁N₃O₂352341-26-5

Products

Catalogue NumberPackaging Qty/Pack
119113-5MG Glass bottle 5 mg
Description
OverviewA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
Catalogue Number119113
Brand Family Calbiochem®
Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
References
ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
Product Information
CAS number352341-26-5
DeclarationMarketed by Promega Corp. under the registered trademarks.
FormOff-white solid
Hill FormulaC₁₄H₁₁N₃O₂
Chemical formulaC₁₄H₁₁N₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem Certificates of Analysis

TitleLot Number
119113

References

Reference overview
Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
DescriptionA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number352341-26-5
Chemical formulaC₁₄H₁₁N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.