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119114 Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem

119114
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₄N₂S10205-56-8

Products

Catalogue NumberPackaging Qty/Pack
119114-5MG Glass bottle 5 mg
Description
OverviewA 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µM against Promega's Kinase-Glo®; ineffective against Kinase-Glo® Plus and Kinase-Glo® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
Catalogue Number119114
Brand Family Calbiochem®
Synonyms4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
References
ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
Product Information
CAS number10205-56-8
DeclarationMarketed by Promega Corp. under the registered trademarks.
FormPale green solid
Hill FormulaC₁₅H₁₄N₂S
Chemical formulaC₁₅H₁₄N₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 22-26-36

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem Certificates of Analysis

TitleLot Number
119114

References

Reference overview
Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
Synonyms4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
DescriptionA 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µM against Promega's Kinase-Glo®; ineffective against Kinase-Glo® Plus and Kinase-Glo® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
FormPale green solid
Intert gas (Yes/No) Packaged under inert gas
CAS number10205-56-8
Chemical formulaC₁₅H₁₄N₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (0.5 mg/ml) or Ethanol (3 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.