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324473 PARP Inhibitor IX, EB-47 - Calbiochem

324473
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₄H₂₇N₉O₆·2HCl·2H₂O

Products

Catalogue NumberPackaging Qty/Pack
324473-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC50 = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
Catalogue Number324473
Brand Family Calbiochem®
References
ReferencesJagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
Chemical formulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPARP-1
Primary Target IC<sub>50</sub>45 nM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

PARP Inhibitor IX, EB-47 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PARP Inhibitor IX, EB-47 - Calbiochem Certificates of Analysis

TitleLot Number
324473

References

Reference overview
Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2008 RFH
DescriptionA cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC50 = 45 nM). Reported to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (50 mg/ml)
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesJagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.