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234490 PD 153035 - CAS 153436-54-5 - Calbiochem

234490
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₆H₁₄BrN₃O₂153436-54-5

Products

Catalogue NumberPackaging Qty/Pack
234490-1MG Plastic ampoule 1 mg
Description
OverviewAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
Catalogue Number234490
Brand Family Calbiochem®
SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
References
ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
Fry, D.W., et al. 1994. Science 265, 1093.
Product Information
CAS number153436-54-5
ATP CompetitiveY
DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
FormWhite solid
Hill FormulaC₁₆H₁₄BrN₃O₂
Chemical formulaC₁₆H₁₄BrN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>25 pM
Primary Target K<sub>i</sub>6 pM against epidermal growth factor receptor (EGFR)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

PD 153035 - CAS 153436-54-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PD 153035 - CAS 153436-54-5 - Calbiochem Certificates of Analysis

TitleLot Number
234490

References

Reference overview
Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
Fry, D.W., et al. 1994. Science 265, 1093.

Technical Info

Title
JAK/STAT Signaling Research Focus

Citations

Title
  • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision05-April-2011 RFH
    SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
    DescriptionAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
    FormWhite solid
    CAS number153436-54-5
    Chemical formulaC₁₆H₁₄BrN₃O₂
    Structure formulaStructure formula
    Purity≥97% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage -20°C
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
    Fry, D.W., et al. 1994. Science 265, 1093.
    Citation
  • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.