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178281 p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem

178281
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Overview

Replacement Information

Key Spec Table

CAS #
74938-88-8

Products

Catalogue NumberPackaging Qty/Pack
178281-5MG Plastic ampoule 5 mg
Description
OverviewAlternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.
Catalogue Number178281
Brand Family Calbiochem®
Synonymsp-Amidinophenylmethylsulfonylfluoride, HCl
References
ReferencesCole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry 19, 4859.
Product Information
CAS number74938-88-8
ATP CompetitiveN
FormWhite solid
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targettrypsin-like serine proteases
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem Certificates of Analysis

TitleLot Number
178281

References

Reference overview
Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry 19, 4859.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2008 RFH
Synonymsp-Amidinophenylmethylsulfonylfluoride, HCl
DescriptionAn alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.
FormWhite solid
CAS number74938-88-8
Purity≥97% by HPLC
SolubilityH₂O (25 mg/ml)
Storage +2°C to +8°C
Protect from moisture
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Standard Handling
ReferencesCole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry 19, 4859.