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344301 sFRP Inhibitor II - CAS 302804-57-5 - Calbiochem

344301
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₄H₁₇N₃O₄S₂302804-57-5

Products

Catalogue NumberPackaging Qty/Pack
344301-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable iminooxothiazolidine compound that is shown to counteract the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and restore cellular response to Wnt-3 stimulation (by a 2.3-fold enhancement at 15 µM) in U2OS-based reporter assays. Also reported to increase total bone area and the number of osteoblasts (by ~20% and ~45%, respectively) in a murine ex vivo calvarial bone formation assay.
Catalogue Number344301
Brand Family Calbiochem®
SynonymsWnt Pathway Activator V, 2-(2-(2-Imino-4-oxo-thiazolidin-5-yl)-acetylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester, Secreted Frizzled Related Protein-1 Inhibitor II
References
ReferencesShi, M., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6337.
Product Information
CAS number302804-57-5
FormOff-white solid
Hill FormulaC₁₄H₁₇N₃O₄S₂
Chemical formulaC₁₄H₁₇N₃O₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

sFRP Inhibitor II - CAS 302804-57-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

sFRP Inhibitor II - CAS 302804-57-5 - Calbiochem Certificates of Analysis

TitleLot Number
344301

References

Reference overview
Shi, M., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6337.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
SynonymsWnt Pathway Activator V, 2-(2-(2-Imino-4-oxo-thiazolidin-5-yl)-acetylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester, Secreted Frizzled Related Protein-1 Inhibitor II
DescriptionA cell-permeable iminooxothiazolidine compound that is shown to counteract the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and restore cellular response to Wnt-3 stimulation (by a 2.3-fold enhancement at 15 µM) in U2OS-based reporter assays. Also reported to increase total bone area and the number of osteoblasts (by ~20% and ~45%, respectively) in a murine ex vivo calvarial bone formation assay.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number302804-57-5
Chemical formulaC₁₄H₁₇N₃O₄S₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShi, M., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6337.