191500 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

191500
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₀BrN₃O676596-65-9

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191500-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM), and displays ~100-200 fold greater selectivity over Cdk1/B and Cdk5/p25 (IC50 = 2 µM and 4.2 µM, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 191501).
      Catalogue Number191500
      Brand Family Calbiochem®
      Synonyms1-AKP
      References
      ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
      Product Information
      CAS number676596-65-9
      ATP CompetitiveY
      FormTan solid
      Hill FormulaC₁₅H₁₀BrN₃O
      Chemical formulaC₁₅H₁₀BrN₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGSK-3β
      Primary Target IC<sub>50</sub>18 nM against GSK-3β
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      1-Azakenpaullone - CAS 676596-65-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      1-Azakenpaullone - CAS 676596-65-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      191500

      References

      Reference overview
      Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-December-2010 JSW
      Synonyms1-AKP
      DescriptionA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively).
      FormTan solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number676596-65-9
      Chemical formulaC₁₅H₁₀BrN₃O
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.