100081 14-3-3 Antagonist I, 2-5 - Calbiochem

100081
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₂₃N₆O₈P

Pricing & Availability

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100081-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable dipeptidyl-phosphoserine compound that effectively disrupts 14-3-3 interaction with its ligands (IC50 = 2.6 µM against TMR-GG-RLSHpSSLPG binding to human 14-3-3ς), including Raf-1 and p53. Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (100µM) in a time-dependent manner.
      Catalogue Number100081
      Brand Family Calbiochem®
      Synonyms(S)-2-(2-(4-Azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl-dihydrogen phosphate
      References
      ReferencesWu, H., et al. 2010. Angew. Chem. Int. Ed. 49, 6528.
      Product Information
      FormPale yellow to beige solid
      Hill FormulaC₂₀H₂₃N₆O₈P
      Chemical formulaC₂₀H₂₃N₆O₈P
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      14-3-3 Antagonist I, 2-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      14-3-3 Antagonist I, 2-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      100081

      References

      Reference overview
      Wu, H., et al. 2010. Angew. Chem. Int. Ed. 49, 6528.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-March-2012 JSW
      Synonyms(S)-2-(2-(4-Azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl-dihydrogen phosphate
      DescriptionA cell-permeable dipeptidyl-phosphoserine compound that targets 14-3-3 phosphopeptide binding site and effectively competes against 14-3-3 ligands, including Raf-1 and p53, binding to 14-3-3 (IC50 = 2.6 µM against TMR-GG-RLSHpSSLPG binding to human 14-3-3ς). Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (live cell population after 12 h 100 µM drug treatment = 30% of control). Stability study using A549 cell lysates (100 µM drug in 1 µg/ml lysate) reveals a dephosphorylation t1/2 of ~ 6 hrs and no detectable proteolytic degradation up to 12 hrs.
      FormPale yellow to beige solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₃N₆O₈P
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWu, H., et al. 2010. Angew. Chem. Int. Ed. 49, 6528.