100069 17-DMAG - CAS 467214-21-7 - Calbiochem

100069
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₃₂H₄₈N₄O₈ • HCl467214-21-7

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100069-500UG
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      Plastic ampoule 500 μg
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      Description
      OverviewA potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.
      Catalogue Number100069
      Brand Family Calbiochem®
      SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
      References
      ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
      Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
      Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
      Product Information
      CAS number467214-21-7
      ATP CompetitiveN
      FormPurple solid
      Hill FormulaC₃₂H₄₈N₄O₈ • HCl
      Chemical formulaC₃₂H₄₈N₄O₈ • HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Application17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM).
      Biological Information
      Primary Target17-DMAG
      Primary Target IC<sub>50</sub>GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      17-DMAG - CAS 467214-21-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      100069

      References

      Reference overview
      Tian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
      Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
      Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
      DescriptionA cell-permeable, water soluble, potent anti-tumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen).
      FormPurple solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number467214-21-7
      Chemical formulaC₃₂H₄₈N₄O₈ • HCl
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (5 mg/ml) or H₂O (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
      Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
      Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.