189825 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

189825
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₈H₁₂N₄O₄2353-33-5

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189825-25MG
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      Plastic ampoule 25 mg
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      Description
      OverviewA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826).
      Catalogue Number189825
      Brand Family Calbiochem®
      Synonyms5-Aza-CdR, 5-Aza-dC, 2'-Deoxy-5-azacytidine, Decitabine
      References
      ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
      Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
      Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
      Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
      Haaf, T. 1995. Pharmacol. Ther. 65, 19.
      Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.
      Product Information
      CAS number2353-33-5
      FormLyophilized
      Hill FormulaC₈H₁₂N₄O₄
      Chemical formulaC₈H₁₂N₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Application5-Aza-2ʹ-Deoxycytidine, CAS 2353-33-5, is a cytosine analog that acts as a suicide substrate and inhibits DNA methyltransferase activity.
      Biological Information
      Primary TargetDNA methyltransferase inhibitor
      Purity≥ 98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXZ3012000
      Safety Information
      R PhraseR: 20/21/22-36/37/38-43-61

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      May cause harm to the unborn child.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      189825

      References

      Reference overview
      Eggert, A., et al. 2001. Cancer Res. 61, 1314.
      Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
      Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
      Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
      Haaf, T. 1995. Pharmacol. Ther. 65, 19.
      Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2008 JSW
      Synonyms5-Aza-CdR, 5-Aza-dC, 2'-Deoxy-5-azacytidine, Decitabine
      DescriptionA cytosine analog that acts as a DNA methyltransferase inhibitor. Shown to restore mRNA and protein expression of caspase-8 and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) sensitivity of resistant cell lines. Also reported to enhance apoptosis induced by histone deacetylase (HDAC) inhibitors.
      FormLyophilized
      Intert gas (Yes/No) Packaged under inert gas
      CAS number2353-33-5
      RTECSXZ3012000
      Chemical formulaC₈H₁₂N₄O₄
      Structure formulaStructure formula
      Purity≥ 98% by HPLC
      SolubilityDMSO (25 mg/ml), 50% Acetic Acid (25 mg/ml), or Methanol (1 mg/ml) (warming is required to achieve complete solubilization)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
      Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
      Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
      Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
      Haaf, T. 1995. Pharmacol. Ther. 65, 19.
      Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > DNA Methyltransferase Inhibitors