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508505 A-803467 - CAS 944261-79-4 - Calbiochem

A-803467 - CAS 944261-79-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Sodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467

Primary Target: Nav1.8
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
944261-79-4C₁₉H₁₆ClNO₄
Description
Overview

This product has been discontinued.



A voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥ 1 µM).
Catalogue Number508505
Brand Family Calbiochem®
SynonymsSodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
References
ReferencesJarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.
Product Information
CAS number944261-79-4
FormWhite solid
Hill FormulaC₁₉H₁₆ClNO₄
Chemical formulaC₁₉H₁₆ClNO₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNav1.8
Primary Target IC<sub>50</sub>8 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
508505 0

Documentation

A-803467 - CAS 944261-79-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-January-2014 JSW
SynonymsSodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
DescriptionA voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥ 1 µM).
FormWhite solid
CAS number944261-79-4
Chemical formulaC₁₉H₁₆ClNO₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM) or EtOH (25 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.