100110 AAPH - CAS 2997-92-4 - Calbiochem

100110
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₈H₁₈N₆ · 2HCl2997-92-4

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100110-1GM
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      Description
      OverviewA heat-sensitive, water-soluble, free radical initiator that induces oxidative stress by causing cellular damage associated with lipid peroxidation, protein modification, hemoglobin oxidation, and DNA strand breakage. Reported to induce apoptosis in HL-60 cells via activation of caspase-3.
      Catalogue Number100110
      Brand Family Calbiochem®
      SynonymsABAP, 2,2ʹ-Azobis-(2-amidinopropane), 2HCl, 2,2ʹ-Azobis-(2-methylpropionamidine), 2HCl
      References
      ReferencesIshika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
      Raneva, V., et al. 2001. Lipids 36, 1111.
      Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
      Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
      Bassett, C.N., et al. 1999. Lipids 34, 1273.
      Viner, R.I., et al. 1997. Biochemistry 36, 7706.
      Kanno, T., et al. 1994. Free Radic. Res. 21, 223.
      Product Information
      CAS number2997-92-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₈N₆ · 2HCl
      Chemical formulaC₈H₁₈N₆ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAAPH, CAS 2997-92-4, is a heat-sensitive, water-soluble, free radical initiator. Induces oxidative stress to cause lipid peroxidation, protein modification & DNA strand breakage.
      Biological Information
      Primary TargetFree radical initiator that induces oxidative stress
      Purity≥96% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUE4575500
      Safety Information
      R PhraseR: 20/21/22-36/37/38-42/43

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 24 h at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AAPH - CAS 2997-92-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AAPH - CAS 2997-92-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      100110

      References

      Reference overview
      Ishika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
      Raneva, V., et al. 2001. Lipids 36, 1111.
      Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
      Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
      Bassett, C.N., et al. 1999. Lipids 34, 1273.
      Viner, R.I., et al. 1997. Biochemistry 36, 7706.
      Kanno, T., et al. 1994. Free Radic. Res. 21, 223.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-June-2008 JSW
      SynonymsABAP, 2,2ʹ-Azobis-(2-amidinopropane), 2HCl, 2,2ʹ-Azobis-(2-methylpropionamidine), 2HCl
      DescriptionA heat-sensitive, water-soluble, free radical initiator that induces oxidative stress by causing cellular damage associated with lipid peroxidation, protein modification, hemoglobin oxidation, and DNA strand breakage. Reported to induce apoptosis in HL-60 cells via activation of caspase-3 by lysosomal cysteine proteases. Particularly useful in inducing cell death at hyperthermic temperatures.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number2997-92-4
      RTECSUE4575500
      Chemical formulaC₈H₁₈N₆ · 2HCl
      Structure formulaStructure formula
      Purity≥96% by titration
      SolubilityH₂O (20 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 24 h at 4°C.
      Toxicity Harmful
      ReferencesIshika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
      Raneva, V., et al. 2001. Lipids 36, 1111.
      Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
      Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
      Bassett, C.N., et al. 1999. Lipids 34, 1273.
      Viner, R.I., et al. 1997. Biochemistry 36, 7706.
      Kanno, T., et al. 1994. Free Radic. Res. 21, 223.