121765 AG 825 - CAS 149092-50-2 - Calbiochem

121765
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₁₅N₃O₃S₂149092-50-2

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121765-2MG
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      Plastic ampoule 2 mg
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      Description
      OverviewA potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50 = 0.35 µM) relative to HER1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
      Catalogue Number121765
      Brand Family Calbiochem®
      Synonyms4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
      References
      ReferencesAshton, J.M., et al. 2012. Cell Stem Cell 11, 359.
      Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
      Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
      Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.
      Product Information
      CAS number149092-50-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₅N₃O₃S₂
      Chemical formulaC₁₉H₁₅N₃O₃S₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHER2
      Primary Target IC<sub>50</sub>0.35 µM against HER2
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AG 825 - CAS 149092-50-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AG 825 - CAS 149092-50-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      121765

      References

      Reference overview
      Ashton, J.M., et al. 2012. Cell Stem Cell 11, 359.
      Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
      Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
      Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-March-2015 JSW
      Synonyms4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
      DescriptionA potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC50 = 0.35 µM) relative to HER-1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
      FormYellow solid
      CAS number149092-50-2
      Chemical formulaC₁₉H₁₅N₃O₃S₂
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAshton, J.M., et al. 2012. Cell Stem Cell 11, 359.
      Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
      Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
      Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.