208721 ALLM - CAS 110115-07-6 - Calbiochem

208721
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Key Spec Table

Empirical FormulaCAS #
C₁₉H₃₅N₃O₄S110115-07-6

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208721-25MG
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      Plastic ampoule 25 mg
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      Description
      OverviewCell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome.
      Catalogue Number208721
      Brand Family Calbiochem®
      SynonymsCalpain Inhibitor II
      References
      ReferencesRavid, T., et al. 2000. J. Biol. Chem. 275, 35840.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
      Koohmaraie, M. 1992. Biochemie 74, 239.
      Pinter, M., et al. 1992. Biochemistry 31, 8201.
      Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
      Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
      Product Information
      CAS number110115-07-6
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₉H₃₅N₃O₄S
      Chemical formulaC₁₉H₃₅N₃O₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcalpain-1
      Primary Target K<sub>i</sub>120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
      Purity>95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceN-Acetyl-Leu-Leu-Met
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ALLM - CAS 110115-07-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ALLM - CAS 110115-07-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      208721

      References

      Reference overview
      Ravid, T., et al. 2000. J. Biol. Chem. 275, 35840.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
      Koohmaraie, M. 1992. Biochemie 74, 239.
      Pinter, M., et al. 1992. Biochemistry 31, 8201.
      Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
      Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Proteasomes Technical Bulletin

      Citations

      Title
    • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      SynonymsCalpain Inhibitor II
      DescriptionA cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
      FormOff-white solid
      CAS number110115-07-6
      Chemical formulaC₁₉H₃₅N₃O₄S
      Peptide SequenceN-Acetyl-Leu-Leu-Met
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (5 mg/ml), Ethanol (5 mg/ml), and Methanol (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRavid, T., et al. 2000. J. Biol. Chem. 275, 35840.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
      Koohmaraie, M. 1992. Biochemie 74, 239.
      Pinter, M., et al. 1992. Biochemistry 31, 8201.
      Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
      Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
      Citation
    • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.
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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors