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SCC429 ANBL-6 Plasma Cell Myeloma Cell Line

ANBL-6 is a highly representative cellular model of multiple myeloma.

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SCC429
≥1X10⁶ cells/vial   
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Overview

Replacement Information
Description
Catalogue NumberSCC429
DescriptionANBL-6 Plasma Cell Myeloma Cell Line
OverviewANBL-6 is a well-established model for MM.3 In culture ANBL-6 cell proliferation is dependent on IL-6, a critical component of the bone marrow microenvironment supporting tumor growth.2 Transcriptomic analysis of ANBL-6 cells demonstrated a high correlation with genetic signatures of primary MM tumors.2 ANBL-6 cells home to hematopoietic tissues in a mouse model, with a growth phenotype characteristic of smoldering (indolent) rather than an aggressive form of MM.2 Although derived from peripheral blood, ANBL-6 recapitulates many of the phenotypes associated with primary plasma cell tumors in the bone marrow. ANBL-6 is a highly representative cellular model of multiple myeloma.
Alternate Names
  • ANBL6
Background InformationMultiple myeloma (MM) is a cancer of the plasma cells originating in bone marrow. Although a rare cancer, there is no cure and only 54% of patients diagnosed with MM survive beyond 5 years.1 The vast majority of MM cases are known as smoldering or asymptomatic MM, wherein a small population of aberrant plasma cells resides in the bone marrow.2 Most MM cell line models are not derived from originating tissue but rather peripheral blood, raising questions of how closely these lines reflect the characteristics of the disease in the originating hematopoietic environment.2

Source
The ANBL-6 cell line was isolated from peripheral blood of a 67-year old female patient with myeloma.3

References
1. Cancer Statistics: Multiple Myeloma https://www.cancer.net/cancer-types/multiple-myeloma/statistics Science 2004; 306(5694): 269-71.
2. Leukemia 2020; 34(10): 2754-2765.
3. Cancer Res 1993; 53(21): 5320-5327.
References
Product Information
Quality LevelMQ100
Applications
ApplicationANBL-6 is a highly representative cellular model of multiple myeloma.
Key Applications
  • Cell Culture
Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
Biological Information
Cell Line Type
  • Cancer Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance• Each vial contains ≥ 1X106 viable cells.
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
• Cells are negative for mycoplasma contamination.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsANBL-6 Human Plasma Cell Myeloma Cell Line should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Packaging Information
Material Size≥1X10⁶ cells/vial
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCC429 04065267461236