189299 ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem

189299
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₁H₁₇N₅O₂220036-08-8

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
189299-10MG
Retrieving availability...
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki = 2.5 µM for CDK1, and Ki = 1.3 µM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50 = 6.7 µM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 µM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells.
      Catalogue Number189299
      Brand Family Calbiochem®
      SynonymsATR Inhibitor, NU6027, 2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, CDK2 Inhibitor, NU6027
      References
      ReferencesPeasland, A., et al. 2011., Br J Cancer. 105, 372.
      Arris, C.E, et al. 2000., J Med Chem. 43, 2797.
      Product Information
      CAS number220036-08-8
      FormReddish-purple powder
      Hill FormulaC₁₁H₁₇N₅O₂
      Chemical formulaC₁₁H₁₇N₅O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      189299

      References

      Reference overview
      Peasland, A., et al. 2011., Br J Cancer. 105, 372.
      Arris, C.E, et al. 2000., J Med Chem. 43, 2797.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-May-2012 JSW
      SynonymsATR Inhibitor, NU6027, 2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, CDK2 Inhibitor, NU6027
      DescriptionA cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki = 2.5 µM for CDK1, and Ki = 1.3 µM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50 = 6.7 µM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 µM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells.
      FormReddish-purple powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220036-08-8
      Chemical formulaC₁₁H₁₇N₅O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml; clear, blue solution)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPeasland, A., et al. 2011., Br J Cancer. 105, 372.
      Arris, C.E, et al. 2000., J Med Chem. 43, 2797.