182705 AhR Antagonist - CAS 301326-22-7 - Calbiochem

182705
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₁₉H₁₉N₅O301326-22-7

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182705-10MG
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      Description
      OverviewA cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cells in vitro (IC50 = 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in mice in vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 µM.
      Catalogue Number182705
      Brand Family Calbiochem®
      Synonyms2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4-o-tolyl-azophenyl)-amide, CH-223191
      References
      ReferencesKim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.
      Product Information
      CAS number301326-22-7
      ATP CompetitiveN
      FormOrange-brown
      Hill FormulaC₁₉H₁₉N₅O
      Chemical formulaC₁₉H₁₉N₅O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAhR (aryl hydrocarbon receptor)
      Primary Target IC<sub>50</sub>30 nM in blocking TCDD-induced AhR transcription activity in HepG2 cells in vitro
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AhR Antagonist - CAS 301326-22-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AhR Antagonist - CAS 301326-22-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      182705

      References

      Reference overview
      Kim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4-o-tolyl-azophenyl)-amide, CH-223191
      DescriptionA cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cells in vitro (IC50 = 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in mice in vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 µM.
      FormOrange-brown
      Intert gas (Yes/No) Packaged under inert gas
      CAS number301326-22-7
      Chemical formulaC₁₉H₁₉N₅O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesKim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.