124020 Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

124020
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Key Spec Table

Empirical FormulaCAS #
C₂₀H₂₅ClN₂O • HCl925681-41-0

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124020-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039).
      Catalogue Number124020
      Brand Family Calbiochem®
      Synonyms10-DEBC HC, 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP
      References
      ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
      Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
      Product Information
      CAS number925681-41-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₂₅ClN₂O • HCl
      Chemical formulaC₂₀H₂₅ClN₂O • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAkt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub><5 µM against Akt ; 2-5 µM against growth of Rh (rhabdomyosarcoma) cell lines
      Secondary targetRn cell lines (IC₅₀ = 2-5 µM)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Akt Inhibitor X - CAS 925681-41-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Akt Inhibitor X - CAS 925681-41-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      124020

      References

      Reference overview
      Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
      Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.

      Brochure

      Title
      Akt
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-September-2010 JSW
      Synonyms10-DEBC HC, 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP
      DescriptionA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 μM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number925681-41-0
      Chemical formulaC₂₀H₂₅ClN₂O • HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
      Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.