172060 Andrographolide - CAS 5508-58-7 - Calbiochem

172060
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₀H₃₀O₅5508-58-7

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172060-50MG
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      Plastic ampoule 50 mg
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      Description
      OverviewA bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
      Catalogue Number172060
      Brand Family Calbiochem®
      SynonymsAndro
      References
      ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
      Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
      Yu, B.C., et al. 2003. Planta Med. 69, 1075.
      Product Information
      CAS number5508-58-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₀H₃₀O₅
      Chemical formulaC₂₀H₃₀O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNF-κB and AP-1 activation
      Primary Target IC<sub>50</sub>≤ 15 µM against NF-κB and AP-1 activation
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLU3490750
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Andrographolide - CAS 5508-58-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Andrographolide - CAS 5508-58-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      172060

      References

      Reference overview
      Xia, Y.F., et al. 2004. J. Immunol. 173, 4207.
      Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
      Yu, B.C., et al. 2003. Planta Med. 69, 1075.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-April-2008 RFH
      SynonymsAndro
      DescriptionAn irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5508-58-7
      RTECSLU3490750
      Chemical formulaC₂₀H₃₀O₅
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (15 mg/ml) or Chloroform:Methanol (1:1) (10 mg/ml). Use only fresh DMSO.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 633
      ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
      Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
      Yu, B.C., et al. 2003. Planta Med. 69, 1075.