176708 Angiostatin K1-3, Human, Recombinant, E. coli

176708
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176708-250UG
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      Glass bottle 250 μg
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      Description
      OverviewRecombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
      Catalogue Number176708
      Brand Family Calbiochem®
      SynonymsAng K1-3, K1-3, rHuAng K1-3
      References
      ReferencesCao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
      Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
      Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
      Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
      O'Rieilly, M.S., et al. 1994. Cell 79, 315.
      Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
      Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
      Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.
      Product Information
      FormLyophilized powder
      FormulationLyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC and SDS-PAGE
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Angiostatin K1-3, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Angiostatin K1-3, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      176708

      References

      Reference overview
      Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
      Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
      Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
      Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
      O'Rieilly, M.S., et al. 1994. Cell 79, 315.
      Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
      Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
      Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-July-2010 RFH
      SynonymsAng K1-3, K1-3, rHuAng K1-3
      DescriptionRecombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
      FormLyophilized powder
      FormulationLyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
      Purity≥95% by HPLC and SDS-PAGE
      SolubilityH2O or Aqueous Buffer Containing 0.1% BSA
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
      Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
      Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
      Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
      O'Rieilly, M.S., et al. 1994. Cell 79, 315.
      Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
      Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
      Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.