182541 Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

182541
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₁₇H₁₁N₅112809-51-5

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182541-25MG
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      Glass bottle 25 mg
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      Description
      OverviewAn orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
      Catalogue Number182541
      Brand Family Calbiochem®
      Synonyms4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
      References
      ReferencesHou, X., et al. 2011. Cancer Res. 71, 7597.
      Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
      Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
      Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.
      Product Information
      CAS number112809-51-5
      FormWhite powder
      Hill FormulaC₁₇H₁₁N₅
      Chemical formulaC₁₇H₁₁N₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      182541

      References

      Reference overview
      Hou, X., et al. 2011. Cancer Res. 71, 7597.
      Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
      Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
      Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2012 JSW
      Synonyms4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
      DescriptionAn orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number112809-51-5
      Chemical formulaC₁₇H₁₁N₅
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml; clear, colorless solution) or Ethanol (< 5 mg/ml; partially soluble)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHou, X., et al. 2011. Cancer Res. 71, 7597.
      Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
      Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
      Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.