189513 Autotaxin Inhibitor IV, HA155 - Calbiochem

189513
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₄H₁₉BFNO₅S

Pricing & Availability

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189513-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA ~5-fold more potent (IC50 = 5.7 nM) para-isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat. No. 189511) that efficiently blocks thrombin-stimulated lysophosphatidic acid secretion in platelets and in mammalian cells.
      Catalogue Number189513
      Brand Family Calbiochem®
      SynonymsAtx Inhibitor IV, HA155, (Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid
      References
      ReferencesFulkerson, Z., et al. 2011. J. Biol. Chem. 286, 34654.
      Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol. 18, 198.
      Albers, H.M.H.G., et al. 2011. J. Med. Chem. 54, 4619.
      Albers, H.M.H.G., et al. 2010. J. Med. Chem. 53, 4958.
      Product Information
      FormYellow powder
      Hill FormulaC₂₄H₁₉BFNO₅S
      Chemical formulaC₂₄H₁₉BFNO₅S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Autotaxin Inhibitor IV, HA155 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Fulkerson, Z., et al. 2011. J. Biol. Chem. 286, 34654.
      Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol. 18, 198.
      Albers, H.M.H.G., et al. 2011. J. Med. Chem. 54, 4619.
      Albers, H.M.H.G., et al. 2010. J. Med. Chem. 53, 4958.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2012 JSW
      SynonymsAtx Inhibitor IV, HA155, (Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid
      DescriptionA ~5-fold more potent (IC50 = 5.7 nM) para-isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat. No. 189511) that efficiently blocks thrombin-stimulated lysophosphatidic acid secretion in platelets and in mammalian cells.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₁₉BFNO₅S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFulkerson, Z., et al. 2011. J. Biol. Chem. 286, 34654.
      Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol. 18, 198.
      Albers, H.M.H.G., et al. 2011. J. Med. Chem. 54, 4619.
      Albers, H.M.H.G., et al. 2010. J. Med. Chem. 53, 4958.