197228 BCRP Inhibitor IV, YHO-13351 - Calbiochem

197228
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₃₃N₃O₄S • CH₃SO₃H

Pricing & Availability

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197228-25MG
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      Glass bottle 25 mg
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      Description
      OverviewAn in vivo bioavailable (~87%; t1/2 < 5 mins. during p.o. and i.v. administration) and highly water soluble ( >100 mg/ml) diethylaminoacetate prodrug of YHO-13177 (Cat. No. 197227) that reverses BCRP-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200 mg/kg, i.p.).
      Catalogue Number197228
      Brand Family Calbiochem®
      SynonymsDiethylaminoacetic acid, 1-(5-((Z)-2-cyano-2- (3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate
      References
      ReferencesYamazaki, R., et al. 2011. Mol. Cancer Ther. 10, 1252.
      Product Information
      FormYellow solid
      Hill FormulaC₂₆H₃₃N₃O₄S • CH₃SO₃H
      Chemical formulaC₂₆H₃₃N₃O₄S • CH₃SO₃H
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      BCRP Inhibitor IV, YHO-13351 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      BCRP Inhibitor IV, YHO-13351 - Calbiochem Certificates of Analysis

      TitleLot Number
      197228

      References

      Reference overview
      Yamazaki, R., et al. 2011. Mol. Cancer Ther. 10, 1252.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-September-2012 JSW
      SynonymsDiethylaminoacetic acid, 1-(5-((Z)-2-cyano-2- (3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate
      DescriptionAn in vivo bioavailable (~87%; t1/2 < 5 mins. during p.o. and i.v. administration) and highly water soluble ( >100 mg/ml) diethylaminoacetate prodrug of YHO-13177 (Cat. No. 197227) that reverses BCRP-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200 mg/kg, i.p.).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₃₃N₃O₄S • CH₃SO₃H
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (25 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesYamazaki, R., et al. 2011. Mol. Cancer Ther. 10, 1252.