197900 BEC, Hydrochloride - Calbiochem

197900
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅H₁₂BNO₄S · HCl

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197900-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.
      Catalogue Number197900
      Brand Family Calbiochem®
      Synonyms(S)-(2-Boronoethyl)-L-cysteine, HCI)
      References
      ReferencesColleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
      Kim, N.N., et al. 2001. Biochemistry 40, 2678.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₅H₁₂BNO₄S · HCl
      Chemical formulaC₅H₁₂BNO₄S · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationBEC, Hydrochloride, CAS 63107-40-4, is a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human type II arginase). Does not inhibit nitric oxide synthase.
      Biological Information
      Primary Targetarginase 1, arginase 2
      Primary Target K<sub>i</sub>310 nM for human recombinant type II arginase, pH 7.5
      Purity≥97% by NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      BEC, Hydrochloride - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      BEC, Hydrochloride - Calbiochem Certificates of Analysis

      TitleLot Number
      197900

      References

      Reference overview
      Colleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
      Kim, N.N., et al. 2001. Biochemistry 40, 2678.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2010 RFH
      Synonyms(S)-(2-Boronoethyl)-L-cysteine, HCI)
      DescriptionA boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₅H₁₂BNO₄S · HCl
      Structure formulaStructure formula
      Purity≥97% by NMR
      SolubilityH₂O (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
      Toxicity Harmful
      ReferencesColleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
      Kim, N.N., et al. 2001. Biochemistry 40, 2678.