203715 BQ-610 - Calbiochem

203715
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₃₆H₄₇N₇O₆
      Description
      OverviewA highly selective ETA receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC50 = 28.2 nM). BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in porcine aortic smooth muscle membrane assay.
      Catalogue Number203715
      Brand Family Calbiochem®
      References
      ReferencesBeyer, M.E., et al. 1999. Hypertension 33, 145.
      Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
      Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
      Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
      Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized powder
      FormulationSupplied as an ammonium salt.
      Hill FormulaC₃₆H₄₇N₇O₆
      Chemical formulaC₃₆H₄₇N₇O₆
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetETA receptor antagonist
      Primary Target IC<sub>50</sub>20 nM as ETA receptor antagonist that attenuates ET-induced reduction in cardiac output
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceHomopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      BQ-610 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      BQ-610 - Calbiochem Certificates of Analysis

      TitleLot Number
      203715

      References

      Reference overview
      Beyer, M.E., et al. 1999. Hypertension 33, 145.
      Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
      Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
      Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
      Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-April-2010 JSW
      DescriptionA highly selective endothelin A (ETA) receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Inhibits ET-1 induced mitogenesis in airway smooth muscle cells in a concentration-dependent manner (IC50 = 20 nM). Also inhibits ET-1 and ET-3 induced activation of adenylate cyclase (IC50 = 28.2 nM). Has been shown to prevent endothelin-induced vasoconstriction. BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in a porcine aortic smooth muscle assay.
      FormWhite lyophilized powder
      FormulationSupplied as an ammonium salt.
      Chemical formulaC₃₆H₄₇N₇O₆
      Peptide SequenceHomopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4
      Purity≥90% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBeyer, M.E., et al. 1999. Hypertension 33, 145.
      Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
      Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
      Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
      Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.