196810 Bax-Inhibiting Peptide, V5 - Calbiochem

196810
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₇H₅₀N₆O₆S

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196810-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain that offers cytoprotection. Functions as effectively as the Caspase Inhibitor VI (Z-VAD-FMK; Cat. No. 219007) for Bax-mediated apoptosis (~50-200 µM). Also effectively blocks caspase-independent necrotic cell death. Shown to be Ku70 competitive, interact with Bax, prevent its conformational change and mitochondrial translocation. Displays extended stability in culture medium (~3 days). Negative control peptide is also available (Cat. No. 196811).
      Catalogue Number196810
      Brand Family Calbiochem®
      SynonymsBIP-V5, H-VPMLK-OH
      References
      ReferencesYoshida, T., et al. 2004. Biochem. Biophys. Res. Commun. 321, 961.
      Sawada, M., et al. 2003. Nature Cell Biol. 5, 352.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₇H₅₀N₆O₆S
      Chemical formulaC₂₇H₅₀N₆O₆S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationBax-Inhibiting Peptide, V5, CAS 579492-81-2, is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 µM).
      Biological Information
      Primary TargetBax mediated apoptosis
      Primary Target IC<sub>50</sub>50-200 µM against Bax mediated apoptosis
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Val-Pro-Met-Leu-Lys-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Storage in glass vials is not recommended as loss of activity may occur.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Bax-Inhibiting Peptide, V5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Bax-Inhibiting Peptide, V5 - Calbiochem Certificates of Analysis

      TitleLot Number
      196810

      References

      Reference overview
      Yoshida, T., et al. 2004. Biochem. Biophys. Res. Commun. 321, 961.
      Sawada, M., et al. 2003. Nature Cell Biol. 5, 352.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      SynonymsBIP-V5, H-VPMLK-OH
      DescriptionA cell-permeable pentapeptide derived from the Ku70-Bax inhibiting domain that has been shown to offer protection against apoptosis in cells of human, mouse, rant, and porcine origin. Reported to function as effectively as the caspase inhibitor, Z-VAD-FMK (Caspase Inhibitor VI, Cat. No. 219007) for Bax-mediated apoptosis (~50-200 µM). Also reported to effectively block caspase-independent necrotic cell death. Shown to interact with Bax in a Ku70-competitive manner and prevent its conformational change and mitochondrial translocation. Displays extended stability in culture medium (~3 days).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₇H₅₀N₆O₆S
      Peptide SequenceH-Val-Pro-Met-Leu-Lys-OH
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Storage in glass vials is not recommended as loss of activity may occur.
      Toxicity Standard Handling
      ReferencesYoshida, T., et al. 2004. Biochem. Biophys. Res. Commun. 321, 961.
      Sawada, M., et al. 2003. Nature Cell Biol. 5, 352.