203291 Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem

203291
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₅H₂₄N₄O₂ · HCl176504-36-2

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
203291-1MG
Retrieving availability...
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 1 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      203291-250UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 250 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewAn enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A at much higher concentrations (Ki = 2 µM).
          Catalogue Number203291
          Brand Family Calbiochem®
          Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
          References
          ReferencesLe Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
          Kuchera, S., et al. 1993. Agents Actions 39, C169.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
          Product Information
          CAS number176504-36-2
          ATP CompetitiveY
          FormOrange-red solid
          Hill FormulaC₂₅H₂₄N₄O₂ · HCl
          Chemical formulaC₂₅H₂₄N₄O₂ · HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetProtein kinase C
          Primary Target K<sub>i</sub>10 nM against protein kinase C
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          203291

          References

          Reference overview
          Le Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
          Kuchera, S., et al. 1993. Agents Actions 39, C169.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

          Citations

          Title
        • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
        • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-January-2010 RFH
          Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
          DescriptionA reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). Inhibits protein kinase A at much higher concentrations (Ki = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
          FormOrange-red solid
          CAS number176504-36-2
          Chemical formulaC₂₅H₂₄N₄O₂ · HCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml) or H₂O (10 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Standard Handling
          ReferencesLe Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
          Kuchera, S., et al. 1993. Agents Actions 39, C169.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
          Citation
        • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
        • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.