203401 Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem

203401
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CAS #
9041-93-4

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203401-10MG
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      Glass bottle 10 mg
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      Description
      OverviewMixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
      Catalogue Number203401
      Brand Family Calbiochem®
      References
      ReferencesTounekki, O., et al. 1994. Bull. Cancer 81, 1043.
      Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
      Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
      Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
      Arkin, H., et al. 1989. Cancer Res. 49, 6556.
      Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
      Takita, T., et al. 1968. Antibiotics 21, 79.
      Product Information
      CAS number9041-93-4
      FormWhite to off-white solid
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityPotency: 1.5-2.0 U/mg
      Purity≥90% by HPLC (A₂ + B₂)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEC5991990
      Safety Information
      R PhraseR: 20/21/22-36/37/38-40-42/43

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      Limited evidence of a carcinogenic effect.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      203401

      References

      Reference overview
      Tounekki, O., et al. 1994. Bull. Cancer 81, 1043.
      Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
      Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
      Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
      Arkin, H., et al. 1989. Cancer Res. 49, 6556.
      Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
      Takita, T., et al. 1968. Antibiotics 21, 79.

      Brochure

      Title
      Antibiotics Profiler
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2007 JSW
      DescriptionA mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An antineoplastic agent capable of mimicking apoptosis. Useful in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
      FormWhite to off-white solid
      CAS number9041-93-4
      RTECSEC5991990
      Purity≥90% by HPLC (A₂ + B₂)
      Biological activityPotency: 1.5-2.0 U/mg
      SolubilityH₂O (20 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 1318
      ReferencesTounekki, O., et al. 1994. Bull. Cancer 81, 1043.
      Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
      Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
      Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
      Arkin, H., et al. 1989. Cancer Res. 49, 6556.
      Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
      Takita, T., et al. 1968. Antibiotics 21, 79.