203671 Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem

203671
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₈H₃₅O₇ · 3NH₄1177154-51-6
      Description
      Overview

      This product has been discontinued.



      Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.

      Catalogue Number203671
      Brand Family Calbiochem®
      Synonyms3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid, BA, 3NH₄
      References
      ReferencesHirsch, T., et al. 1998. J. Immunol. 161, 35.
      Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
      Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
      Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
      Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
      Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
      Product Information
      CAS number1177154-51-6
      ATP CompetitiveN
      FormBeige-pink solid
      Hill FormulaC₂₈H₃₅O₇ · 3NH₄
      Chemical formulaC₂₈H₃₅O₇ · 3NH₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationBongkrekic Acid, Triammonium Salt, CAS 1177154-51-6, acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore).
      Biological Information
      Primary TargetMitochondrial mega channel
      Purity≥92% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22-40

      Harmful by inhalation, in contact with skin and if swallowed.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 36-22

      Wear suitable protective clothing.
      Do not breathe dust.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      203671

      References

      Reference overview
      Hirsch, T., et al. 1998. J. Immunol. 161, 35.
      Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
      Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
      Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
      Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
      Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-June-2011 JSW
      Synonyms3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid, BA, 3NH₄
      DescriptionActs as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
      FormBeige-pink solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1177154-51-6
      Chemical formulaC₂₈H₃₅O₇ · 3NH₄
      Structure formulaStructure formula
      Purity≥92% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 1332
      ReferencesHirsch, T., et al. 1998. J. Immunol. 161, 35.
      Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
      Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
      Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
      Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
      Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.