208665 Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem

208665
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Key Spec Table

Empirical FormulaCAS #
C₃₁H₂₃Cl₇N₂O57265-65-3

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208665-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable calmodulin antagonist. At least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain calmodulin-dependent phosphodiesterase (IC50 = 10 nM). An inhibitor of voltage-gated Ca2+ channels. Stimulates the release of nitric oxide in neuroblastoma cells. Also acts as a strong non-competitive inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+-ATPase (Ki = 60 nM). Known to prolong cardiac refractoriness in vivo.
      Note: easily adheres to glass in aqueous solution.
      Catalogue Number208665
      Brand Family Calbiochem®
      SynonymsCompound R 24571
      References
      ReferencesHu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
      Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
      Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys. 296, 175.
      Ichikawa, M., et al. 1991. J. Membrane Biol. 120, 211.
      Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
      Anderson, K.W., et al. 1984. J. Biol. Chem. 259, 11487.
      Gietzen, L., et al. 1982. Biochem. J. 207, 541.
      Van Belle, H. 1981. Cell Calcium 2, 483.
      Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap. 208, 454.
      Product Information
      CAS number57265-65-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₁H₂₃Cl₇N₂O
      Chemical formulaC₃₁H₂₃Cl₇N₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetbrain calmodulin-dependent phosphodiesterase
      Primary Target IC<sub>50</sub>10 nM against brain calmodulin-dependent phosphodiesterase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. DMSO stock solutions are stable for up to 2 months -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      208665

      References

      Reference overview
      Hu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
      Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
      Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys. 296, 175.
      Ichikawa, M., et al. 1991. J. Membrane Biol. 120, 211.
      Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
      Anderson, K.W., et al. 1984. J. Biol. Chem. 259, 11487.
      Gietzen, L., et al. 1982. Biochem. J. 207, 541.
      Van Belle, H. 1981. Cell Calcium 2, 483.
      Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap. 208, 454.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-June-2009 JSW
      SynonymsCompound R 24571
      DescriptionA cell-permeable calmodulin antagonist. An analog of sepazonium that is at least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 10 nM). Inhibits voltage-gated Ca2+ channels and stimulates the release of nitric oxide in neuroblastoma cells. Also, acts as a strong inhibitor of calcium-dependent Ca2+-ATPase in erythrocytes. Known to prolong cardiac refractory period in vivo.
      FormWhite solid
      CAS number57265-65-3
      Chemical formulaC₃₁H₂₃Cl₇N₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or EtOH (10 mg/ml). Note: readily adheres to glass in aqueous solution.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. DMSO stock solutions are stable for up to 2 months -20°C.
      Toxicity Standard Handling
      ReferencesHu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
      Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
      Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys. 296, 175.
      Ichikawa, M., et al. 1991. J. Membrane Biol. 120, 211.
      Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
      Anderson, K.W., et al. 1984. J. Biol. Chem. 259, 11487.
      Gietzen, L., et al. 1982. Biochem. J. 207, 541.
      Van Belle, H. 1981. Cell Calcium 2, 483.
      Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap. 208, 454.