208724 Calpain Inhibitor IV - Calbiochem

208724
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₄₀FN₃O₆

Pricing & Availability

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208724-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA potent, cell-permeable, and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
      Catalogue Number208724
      Brand Family Calbiochem®
      SynonymsZ-LLY-FMK
      References
      ReferencesDutt, P., et al. 1998. FEBS Lett. 436, 367.
      Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
      Product Information
      ATP CompetitiveN
      FormWhite to pale yellow solid
      Hill FormulaC₃₀H₄₀FN₃O₆
      Chemical formulaC₃₀H₄₀FN₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCalpain Inhibitor IV, Z-LLY-FMK, CAS 133410-84-1, is a cell-permeable, potent, irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also blocks cathepsin L activity (k2 = 680,000 M-1s-1).
      Biological Information
      Primary Targetcalpain 2
      Primary Target IC<sub>50</sub>k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L
      Puritysingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Leu-Tyr-CH₂F
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Calpain Inhibitor IV - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Calpain Inhibitor IV - Calbiochem Certificates of Analysis

      TitleLot Number
      208724

      References

      Reference overview
      Dutt, P., et al. 1998. FEBS Lett. 436, 367.
      Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2013 JSW
      SynonymsZ-LLY-FMK
      DescriptionA potent, cell-permeable and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
      FormWhite to pale yellow solid
      Chemical formulaC₃₀H₄₀FN₃O₆
      Peptide SequenceZ-Leu-Leu-Tyr-CH₂F
      Structure formulaStructure formula
      Puritysingle spot by TLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDutt, P., et al. 1998. FEBS Lett. 436, 367.
      Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
      Citation
    • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors