208745 Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem

208745
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₇H₂₅FN₂O₄S190274-53-4

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208745-1MG
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      Plastic ampoule 1 mg
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      208745-5MG
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          Description
          OverviewA potent, cell-permeable, reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and L (IC50 = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured lenses.
          Catalogue Number208745
          Brand Family Calbiochem®
          SynonymsN-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
          References
          ReferencesInoue, J., et al. 2003. J. Med. Chem. 46, 868.
          Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
          Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
          Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
          Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
          Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
          Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.
          Product Information
          CAS number190274-53-4
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patent 6,551,999
          FormWhite lyophilized solid
          Hill FormulaC₁₇H₂₅FN₂O₄S
          Chemical formulaC₁₇H₂₅FN₂O₄S
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetµ-calpain
          Primary Target IC<sub>50</sub>7.5 nM for µ-calpain and 78 nM for m-calpain; 15 nM and 1.6 nM against cathepsin B and L, respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide Sequence4-Fluorophenylsulfonyl-Val-Leu-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          208745

          References

          Reference overview
          Inoue, J., et al. 2003. J. Med. Chem. 46, 868.
          Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
          Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
          Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
          Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
          Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
          Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-February-2014 JSW
          SynonymsN-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
          DescriptionA cell-permeable peptide aldehyde that acts as a potent and reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and cathepsin L (IC50 = 1.6 nM). Reduces βFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation in rats. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured rat lenses.
          FormWhite lyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number190274-53-4
          Chemical formulaC₁₇H₂₅FN₂O₄S
          Peptide Sequence4-Fluorophenylsulfonyl-Val-Leu-CHO
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesInoue, J., et al. 2003. J. Med. Chem. 46, 868.
          Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
          Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
          Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
          Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
          Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
          Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.