138000 D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

138000
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₇H₅NO₂S39793-31-2

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138000-50MG
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      Description
      OverviewA cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
      Catalogue Number138000
      Brand Family Calbiochem®
      Synonyms4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
      References
      ReferencesSmith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
      Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.
      Product Information
      CAS number39793-31-2
      FormBeige solid
      Hill FormulaC₇H₅NO₂S
      Chemical formulaC₇H₅NO₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36/37/39

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      138000

      References

      Reference overview
      Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
      Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-August-2009 RFH
      Synonyms4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
      DescriptionA cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number39793-31-2
      Chemical formulaC₇H₅NO₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (80 mg/ml) or 5% NaOH (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Harmful
      ReferencesSmith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
      Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.