110145 D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem

110145
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₀H₃₉NO₃3102-57-6

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110145-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewBiologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells.
      Catalogue Number110145
      Brand Family Calbiochem®
      SynonymsC₂ Ceramide
      References
      ReferencesWestwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
      Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
      Obeid, L.M., et al. 1993. Science 259, 1769.
      Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
      Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
      Product Information
      CAS number3102-57-6
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₀H₃₉NO₃
      Chemical formulaC₂₀H₃₉NO₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhibits cell growth and induces apoptosis in HL-60 cells
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      110145

      References

      Reference overview
      Westwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
      Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
      Obeid, L.M., et al. 1993. Science 259, 1769.
      Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
      Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.

      Brochure

      Title
      Bioactive Lipids Technical Bulletin
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsC₂ Ceramide
      DescriptionBiologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis of HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A. Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress-activated protein (SAP) kinase in HL-60 human promyelocytic cells.
      FormWhite to off-white solid
      CAS number3102-57-6
      Chemical formulaC₂₀H₃₉NO₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mg/ml), Ethanol (5 mg/ml) or Methanol (5 mg/ml). When diluting into aqueous solution, sonication may be necessary to achieve a uniform suspension.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
      Toxicity Irritant
      ReferencesWestwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
      Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
      Obeid, L.M., et al. 1993. Science 259, 1769.
      Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
      Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.