203695 bpV(phen) - CAS 42494-73-5 - Calbiochem

203695
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
K[VO(O₂)₂C₁₂H₈N₂]42494-73-5

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203695-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 µg/kg in vitro and in vivo for use. Inhibits the in situ dephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50 = 38 nM).
      The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
      Catalogue Number203695
      Brand Family Calbiochem®
      SynonymsPotassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII
      References
      ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
      Drake, P.G., et al. 1996. Endocrinology 137, 4960.
      Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60.
      Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
      Yale, J.F., et al. 1995. Diabetes 44, 1274.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
      Product Information
      CAS number42494-73-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaK[VO(O₂)₂C₁₂H₈N₂]
      Chemical formulaK[VO(O₂)₂C₁₂H₈N₂]
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationbpV(phen, CAS 42494-73-5, is an insulin mimetic and an inhibitor of protein phosphotyrosine phosphatase. More potent in dephosphorylating of autophosphorylated insulin receptor than orthovanadate.
      Biological Information
      Primary TargetPTEN
      Primary Target IC<sub>50</sub>38 nM
      Purity≥99% by ⁵¹V-NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      bpV(phen) - CAS 42494-73-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      bpV(phen) - CAS 42494-73-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      203695

      References

      Reference overview
      Schmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
      Drake, P.G., et al. 1996. Endocrinology 137, 4960.
      Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60.
      Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
      Yale, J.F., et al. 1995. Diabetes 44, 1274.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

      Brochure

      Title
      Protein Phosphatases Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2012 JSW
      SynonymsPotassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII
      DescriptionA potent insulin receptor kinase (IRK) activator and protein phosphotyrosine phosphatase inhibitor. Excellent insulin mimetic for in vitro and in vivo use (15 µg/kg). Inhibits in situ dephosphorylation of autophosphorylated insulin receptors with greater than 1000-fold potency over sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50 = 38 nM). The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number42494-73-5
      Chemical formulaK[VO(O₂)₂C₁₂H₈N₂]
      Structure formulaStructure formula
      Purity≥99% by ⁵¹V-NMR
      SolubilityH₂O (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
      Drake, P.G., et al. 1996. Endocrinology 137, 4960.
      Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60.
      Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
      Yale, J.F., et al. 1995. Diabetes 44, 1274.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.