Cell Culture Solutions for Biopharma Manufacturing

By adopting intensified fed-batch and perfusion processes, biopharmaceutical manufacturers can enhance efficiency, ensure high-quality output, and accelerate speed to market.

• Explore comprehensive solutions to increase productivity and intensify upstream processing in mAb manufacturing.
• Learn about perfusion-specific cell line development and cell clones to streamline your intensified processing.
• Intensify seed train expansion with high cell density cryopreservation.
• Discover how the selection of an appropriate cell retention technology impacts process economics. 

Selecting the right media and feeding strategy, along with ensuring high quality of cell culture media and feeds, is crucial for achieving consistent results and high-quality product output (in cell culture). Success relies on a robust supply chain, effective quality management practices implemented by the supplier, and their expertise in media composition and formulation.

• Explore our comprehensive portfolio of fit-for-purpose solutions for CHO, HEK293, insect cell lines.
• Satisfy the nutritional needs of your cell culture with recombinant supplements, enzymes, and growth factors.
• Reduce media contamination risk with appropriate filtration solutions.
• mAb-specific: Find here selecting CHO media and feeds for traditional, intensified fed-batch and perfusion applications.
• mAb-specific: Implement a tailored feeding strategy to fine-tune protein quality attributes, such as glycosylation, and enhance therapeutic outcomes.

Utilizing custom solutions and tailored service support can significantly improve operational efficiency and product/process? outcomes. It allows you to benefit from external expertise, taking some of the weight off your shoulders and allowing you to focus on your process and product.

• Custom manufacturing of cell culture media, feeds, supplements, buffers, and concentrates supports optimal cell culture performance.
• Custom media development services identify and create tailored solutions that meet your exact needs.
• Cell culture media stability and testing services provide information on media and other components’ shelf life as well as nutritional analysis data.
• Learn how cell culture media fingerprinting enables unparalleled accuracy and efficiency through the simultaneous quantitation of 100+ media components.
• mAb-specific: CHOZN^® Cell line engineering and development services support you through rapid development of high-performing cell lines.

A robust quality management system is crucial for maintaining high safety, consistent quality and reliable performance. By collaborating with us as a trusted supplier that has implemented a robust quality management system and risk mitigation measures, manufacturers can safeguard their production process and ensure compliance while minimizing efforts on their side.

• Explore our global quality management system, raw material and vendor management program for cell culture solutions.
• Learn about the first GMP Guideline for Cell Culture Media, a standard implemented at all our cell culture media manufacturing sites.
• Our Emprove^® Program provides comprehensive technical, regulatory, and supply documentation to support your risk assessment efforts.
• Minimize variability in cell culture performance by understanding the impact of trace element impurities.

Achieving consistent results in cell culture manufacturing requires a deep understanding of the underlying processes. A proactive approach enables manufacturers to make informed adjustments during production, enhancing efficiency and ensuring product quality. By leveraging data-driven insights, organizations can optimize their processes and maintain compliance with industry standards.

• Discover how the implementation of Process Analytical Technologies (PAT) improves process efficiency and control.
• Explore sampling strategies and compare available technologies for reliable process insights.

Transitioning from small-scale to large-scale production, or scaling down for process optimization, presents unique challenges (that can impact efficiency and product quality). Understanding the factors influencing cell growth and productivity at different scales, along with selecting flexible, scalable options, is crucial for successful process development and smooth transfer to production scale.

• Find out more about bioreactor scalability and performance .
• Learn how reliable scale-down models can accelerate process development.
• Explore imMEDIAte ADVANTAGE^® services services for pre-GMP small-scale custom cell culture solutions, supporting your development with a quick turnaround.
• Viral vector-specific: Learn about scalability challenges in AAV manufacturing and discover available solutions.

Successful, consistent operations start with reliable supply. A trusted supplier that supports global manufacturing needs with high-quality solutions and is efficient at a regional level is the foundation for a robust production process.

• Explore how building regional cell culture media supply chains backed by a global quality management system, ensuring consistent quality and reliable supply.
• Discover our new South Korean manufacturing facility for improved in-region for-region supply to the Asia-Pacific region.
• Learn about the first GMP Guideline for Cell Culture Media, a standard implemented at all our cell culture media manufacturing sites.