196878 (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

196878
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Replacement Information

Tabela kluczowych gatunków

Empirical FormulaCAS #
C₁₆H₁₅F₃N₂O₄ 93468-89-4

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
196878-1MG
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Niedostępny w magazynie PLNiedostępny w magazynie PL
Dostępny w magazynie 
Wycofano
Dostępna ograniczona ilość
Dostępność będzie potwierdzona
    Remaining : Will advise
      Remaining : Will advise
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      Ampulka plastikowa 1 mg
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      196878-5MG
      Pobieram informacje o dostępności...
      Niedostępny w magazynie PLNiedostępny w magazynie PL
      Dostępny w magazynie 
      Wycofano
      Dostępna ograniczona ilość
      Dostępność będzie potwierdzona
        Remaining : Will advise
          Remaining : Will advise
          Doradzimy
          Skontaktuj się z Zespołem Obsługi Klienta
          Contact Customer Service

          Ampulka plastikowa 5 mg
          Pobieranie ceny...
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          Description
          OverviewSynthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
          Catalogue Number196878
          Brand Family Calbiochem®
          Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
          References
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
          Product Information
          CAS number93468-89-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₆H₁₅F₃N₂O₄
          Chemical formulaC₁₆H₁₅F₃N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetL-type Ca2+ channel
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          196878

          References

          Przegląd literatury
          Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-February-2009 JSW
          Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
          DescriptionA synthetic dihydropyridine derivative that is an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
          FormYellow solid
          CAS number93468-89-4
          Chemical formulaC₁₆H₁₅F₃N₂O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol (35 mg/ml) or DMSO (35 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
          Toxicity Irritant
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.