124012 Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

124012
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Empirical FormulaCAS #
C₁₃H₁₆N₆O₄ 35943-35-2

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124012-1MG
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      Ampulka plastikowa 1 mg
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      Description
      OverviewA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038).
      Catalogue Number124012
      Brand Family Calbiochem®
      SynonymsNSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
      References
      ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.
      Product Information
      CAS number35943-35-2
      ATP CompetitiveN
      FormSolid
      Hill FormulaC₁₃H₁₆N₆O₄
      Chemical formulaC₁₃H₁₆N₆O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAkt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3.
      Biological Information
      Primary TargetAkt1, Akt 2, Akt3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRY8455000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      124012

      References

      Przegląd literatury
      Karst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.

      Brochure

      Title
      Akt
      Biologics 31.1
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-January-2012 RFH
      SynonymsNSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
      DescriptionA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number35943-35-2
      RTECSRY8455000
      Chemical formulaC₁₃H₁₆N₆O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml). Further dilute at aqueous buffer in low micromolar concentrations.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.