205531 CA-074 Me - Calbiochem

205531
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Replacement Information

Tabela kluczowych gatunków

Empirical Formula
C₁₉H₃₁N₃O₆

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
205531-1MG
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      Ampulka plastikowa 1 mg
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      Description
      OverviewA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
      Catalogue Number205531
      Brand Family Calbiochem®
      SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
      References
      ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
      Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
      Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
      Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₉H₃₁N₃O₆
      Chemical formulaC₁₉H₃₁N₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin B
      Primary Target IC<sub>50</sub>2.24 nM against cathepsin B
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      CA-074 Me - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      CA-074 Me - Calbiochem Certificates of Analysis

      TitleLot Number
      205531

      References

      Przegląd literatury
      Sever, N., et al. 2002. Biol. Chem. 383, 839.
      Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
      Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
      Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.

      Citations

      Tytuł
      IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-May-2008 RFH
      SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
      DescriptionA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
      FormWhite solid
      Chemical formulaC₁₉H₃₁N₃O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
      Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
      Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
      Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
      CitationIM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.