218759 Caspase-8 Inhibitor II - Calbiochem

218759
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Przegląd

Replacement Information

Tabela kluczowych gatunków

Empirical Formula
C₃₀H₄₃FN₄O₁₁

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
218759-1MG
Pobieram informacje o dostępności...
Niedostępny w magazynie PLNiedostępny w magazynie PL
Dostępny w magazynie 
Wycofano
Dostępna ograniczona ilość
Dostępność będzie potwierdzona
    Remaining : Will advise
      Remaining : Will advise
      Doradzimy
      Skontaktuj się z Zespołem Obsługi Klienta
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      Ampulka plastikowa 1 mg
      Pobieranie ceny...
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      218759-250UG
      Pobieram informacje o dostępności...
      Niedostępny w magazynie PLNiedostępny w magazynie PL
      Dostępny w magazynie 
      Wycofano
      Dostępna ograniczona ilość
      Dostępność będzie potwierdzona
        Remaining : Will advise
          Remaining : Will advise
          Doradzimy
          Skontaktuj się z Zespołem Obsługi Klienta
          Contact Customer Service

          Butelka szklana 250 μg
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          Description
          OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.
          Catalogue Number218759
          Brand Family Calbiochem®
          SynonymsZ-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
          References
          ReferencesTakizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
          Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
          Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Product Information
          ATP CompetitiveN
          FormWhite to yellow powder
          Hill FormulaC₃₀H₄₃FN₄O₁₁
          Chemical formulaC₃₀H₄₃FN₄O₁₁
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationCaspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B.
          Biological Information
          Primary Targetcaspase-8
          Puritysingle spot by TLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Caspase-8 Inhibitor II - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Caspase-8 Inhibitor II - Calbiochem Certificates of Analysis

          TitleLot Number
          218759

          References

          Przegląd literatury
          Takizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
          Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
          Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure

          Citations

          Tytuł
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
        • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
        • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
        • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-February-2011 JSW
          SynonymsZ-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
          DescriptionA potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
          FormWhite to yellow powder
          Chemical formulaC₃₀H₄₃FN₄O₁₁
          Peptide SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
          Puritysingle spot by TLC
          SolubilityDMSO (10 mM)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
          Toxicity Standard Handling
          ReferencesTakizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
          Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
          Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Citation
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
        • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
        • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
        • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.