239763 Cycloheximide - CAS 66-81-9 - Calbiochem

Przegląd

Replacement Information

Tabela kluczowych gatunków

Empirical FormulaCAS #
C₁₅H₂₃NO₄ 66-81-9

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
239763-1GM
Pobieram informacje o dostępności...
Niedostępny w magazynie PLNiedostępny w magazynie PL
Dostępny w magazynie 
Wycofano
Dostępna ograniczona ilość
Dostępność będzie potwierdzona
    Remaining : Will advise
      Remaining : Will advise
      Doradzimy
      Skontaktuj się z Zespołem Obsługi Klienta
      Contact Customer Service

      Butelka szklana 1 gm
      Pobieranie ceny...
      Nie udało się pobrać ceny
      Minimum Quantity needs to be mulitiple of
      Na zapytanie Więcej informacji
      Zapisano ()
       
      Poproś o podanie ceny netto
      239763-5GM
      Pobieram informacje o dostępności...
      Niedostępny w magazynie PLNiedostępny w magazynie PL
      Dostępny w magazynie 
      Wycofano
      Dostępna ograniczona ilość
      Dostępność będzie potwierdzona
        Remaining : Will advise
          Remaining : Will advise
          Doradzimy
          Skontaktuj się z Zespołem Obsługi Klienta
          Contact Customer Service

          Butelka szklana 5 gm
          Pobieranie ceny...
          Nie udało się pobrać ceny
          Minimum Quantity needs to be mulitiple of
          Na zapytanie Więcej informacji
          Zapisano ()
           
          Poproś o podanie ceny netto
          Description
          OverviewAn antifungal antibiotic that inhibits protein synthesis in eukaryotes but not prokaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and other cell types. A 100 mg/ml solution of Cycloheximide (Cat. No. 239765) in DMSO (sterile-filtered) is also available.
          Catalogue Number239763
          Brand Family Calbiochem®
          References
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
          Product Information
          CAS number66-81-9
          FormOff-white solid
          Hill FormulaC₁₅H₂₃NO₄
          Chemical formulaC₁₅H₂₃NO₄
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          Biological Information
          Primary TargethFKBP12
          Primary Target K<sub>i</sub>3.4 µM
          Purity≥90% by assay
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMA4375000
          Safety Information
          R PhraseR: 28-40-51/53-61

          Very toxic if swallowed.
          Limited evidence of a carcinogenic effect.
          Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
          May cause harm to the unborn child.
          S PhraseS: 45-53-61

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Avoid release to the environment. Refer to special instructions/safety data sheet.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cycloheximide - CAS 66-81-9 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Cycloheximide - CAS 66-81-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          239763

          References

          Przegląd literatury
          Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.

          Brochure

          Title
          Bulk Product Guide

          Citations

          Tytuł
        • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-March-2019 JSW
          DescriptionAn antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, however it inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
          FormOff-white solid
          CAS number66-81-9
          RTECSMA4375000
          Chemical formulaC₁₅H₂₃NO₄
          Structure formulaStructure formula
          Purity≥90% by assay
          SolubilityChloroform, Ethanol, Methanol, or H₂O (10 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 2728
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
          Citation
        • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.