324800 Epoxomicin, Synthetic - Calbiochem

324800
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Przegląd

Replacement Information

Tabela kluczowych gatunków

Empirical Formula
C₂₈H₅₀N₄O₇

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
324800-100UG
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      Butelka szklana 100 μg
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      Description
      OverviewAn antitumor and anti-inflammatory agent that acts as a potent, highly specific, and irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidyl-glutamyl peptide hydrolyzing (PGPH) activities of the proteasome. Modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z. Does not affect the activities of non-proteasomal proteases such as trypsin, cathepsin B, or chymotrypsin. A 1 mM (50 µg/90 µl) solution of Epoxomicin, Synthetic (Cat. No. 324801) in DMSO is also available.
      Catalogue Number324800
      Brand Family Calbiochem®
      SynonymsProteasome Inhibitor XIV
      References
      ReferencesMeng, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 10403.
      Sin, N., et al. 1999. Bioorg. Med. Chem. Lett. 9, 2283.
      Hanada, M., et al. 1992. J. Antibiot. 45, 1746.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₈H₅₀N₄O₇
      Chemical formulaC₂₈H₅₀N₄O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCT-L,T-L,PGPH activity of proteasome
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Epoxomicin, Synthetic - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Epoxomicin, Synthetic - Calbiochem Certificates of Analysis

      TitleLot Number
      324800

      References

      Przegląd literatury
      Meng, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 10403.
      Sin, N., et al. 1999. Bioorg. Med. Chem. Lett. 9, 2283.
      Hanada, M., et al. 1992. J. Antibiot. 45, 1746.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2008 RFH
      SynonymsProteasome Inhibitor XIV
      DescriptionAn antitumor agent of microbial origin that acts as a potent, highly specific, and irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. Modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z. Epoxomicin also displays potent anti-inflammatory activity in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₈H₅₀N₄O₇
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml) or Methanol (1 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesMeng, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 10403.
      Sin, N., et al. 1999. Bioorg. Med. Chem. Lett. 9, 2283.
      Hanada, M., et al. 1992. J. Antibiot. 45, 1746.