365250 Gö 6976 - CAS 136194-77-9 - Calbiochem

365250
Wyświetl ceny i dostępność

Przegląd

Replacement Information

Tabela kluczowych gatunków

Empirical FormulaCAS #
C₂₄H₁₈N₄O 136194-77-9

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
US1365250-1MG
Pobieram informacje o dostępności...
Niedostępny w magazynie PLNiedostępny w magazynie PL
Dostępny w magazynie 
Wycofano
Dostępna ograniczona ilość
Dostępność będzie potwierdzona
    Remaining : Will advise
      Remaining : Will advise
      Doradzimy
      Skontaktuj się z Zespołem Obsługi Klienta
      Contact Customer Service

      Ampulka plastikowa 1 mg
      Pobieranie ceny...
      Nie udało się pobrać ceny
      Minimum Quantity needs to be mulitiple of
      Na zapytanie Więcej informacji
      Zapisano ()
       
      Poproś o podanie ceny netto
      365250-500UG
      Pobieram informacje o dostępności...
      Niedostępny w magazynie PLNiedostępny w magazynie PL
      Dostępny w magazynie 
      Wycofano
      Dostępna ograniczona ilość
      Dostępność będzie potwierdzona
        Remaining : Will advise
          Remaining : Will advise
          Doradzimy
          Skontaktuj się z Zespołem Obsługi Klienta
          Contact Customer Service

          Ampulka plastikowa 500 μg
          Pobieranie ceny...
          Nie udało się pobrać ceny
          Minimum Quantity needs to be mulitiple of
          Na zapytanie Więcej informacji
          Zapisano ()
           
          Poproś o podanie ceny netto
          Description
          OverviewA cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC α-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isozymes even at micromolar levels. Reported to inhibit PKCµ at higher concentrations (IC50 = 20 nM). A 500 µg/ml solution of Gö 6976 (Cat. No. 365253) in anhydrous DMSO is also available.
          Catalogue Number365250
          Brand Family Calbiochem®
          SynonymsGo 6976, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
          References
          ReferencesGschwendt, M., et al. 1996. FEBS Lett. 392, 77.
          Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
          Martiny-Baron, G.M., et al. 1993. J. Biol. Chem. 268, 9194.
          Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 4674.
          Product Information
          CAS number136194-77-9
          ATP CompetitiveY
          FormOff-white solid
          Hill FormulaC₂₄H₁₈N₄O
          Chemical formulaC₂₄H₁₈N₄O
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>7.9 nM against rat brain PKC; 2.3 nM, 6.2 nM against Ca2+-dependent PKC α-isozyme and PKCβI, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Gö 6976 - CAS 136194-77-9 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Gö 6976 - CAS 136194-77-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          365250

          References

          Przegląd literatury
          Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
          Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
          Martiny-Baron, G.M., et al. 1993. J. Biol. Chem. 268, 9194.
          Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 4674.

          Citations

          Tytuł
        • Elizabeth A. Johnson, et al. (2006) Agonist-selective mechanisms of µ-opioid receptor desensitization in human embryonic kidney 293 cells. Molecular Pharmacology 70, 676-685.
        • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
        • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-January-2010 RFH
          SynonymsGo 6976, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
          DescriptionA cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCα-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.
          FormOff-white solid
          CAS number136194-77-9
          Chemical formulaC₂₄H₁₈N₄O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesGschwendt, M., et al. 1996. FEBS Lett. 392, 77.
          Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
          Martiny-Baron, G.M., et al. 1993. J. Biol. Chem. 268, 9194.
          Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 4674.
          Citation
        • Elizabeth A. Johnson, et al. (2006) Agonist-selective mechanisms of µ-opioid receptor desensitization in human embryonic kidney 293 cells. Molecular Pharmacology 70, 676-685.
        • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
        • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.