361550 GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

361550
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Empirical FormulaCAS #
C₁₆H₁₀BrN₃O₂ 667463-62-9

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
361550-1MG
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      Description
      OverviewA cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available.
      Catalogue Number361550
      Brand Family Calbiochem®
      SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
      References
      ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Product Information
      CAS number667463-62-9
      ATP CompetitiveY
      FormPurple solid
      Hill FormulaC₁₆H₁₀BrN₃O₂
      Chemical formulaC₁₆H₁₀BrN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGSK-3α/β
      Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37

      Do not breathe dust.
      Wear suitable protective clothing and gloves.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      361550

      References

      Przegląd literatury
      Tseng, A-S., et al. 2006. Chem. Biol. 13, 957.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

      Citations

      Tytuł
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
      DescriptionA cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes.
      FormPurple solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number667463-62-9
      Chemical formulaC₁₆H₁₀BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Citation
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
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      Kategorie

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors