407331 ILK inhibitor, Cpd 22 - Calbiochem

407331
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Przegląd

Replacement Information

Tabela kluczowych gatunków

Empirical Formula
C₃₀H₃₀F₃N₅O

Ceny i dostępność

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US1407331-5MG
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      Butelka szklana 5 mg
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      Description
      OverviewA cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 µM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
      Catalogue Number407331
      Brand Family Calbiochem®
      References
      ReferencesLee, S., et al. 2011. J. Med. Chem. 54, 6364
      Product Information
      FormOff-white powder
      Hill FormulaC₃₀H₃₀F₃N₅O
      Chemical formulaC₃₀H₃₀F₃N₅O
      Quality LevelMQ100
      Applications
      ApplicationILK inhibitor, Cpd 22, is a cell-permeable, potent & specific inhibitor of integrin-linked kinase (ILK; IC50 = 600 nM) with anti-proliferative potency against prostrate & breast cancer cell lines.
      Biological Information
      Purity≥94% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ILK inhibitor, Cpd 22 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      ILK inhibitor, Cpd 22 - Calbiochem Certificates of Analysis

      TitleLot Number
      407331

      References

      Przegląd literatury
      Lee, S., et al. 2011. J. Med. Chem. 54, 6364
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-August-2016 JSW
      DescriptionA cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 mM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₃₀F₃N₅O
      Purity≥94% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, S., et al. 2011. J. Med. Chem. 54, 6364