234491 InSolution™ PD 153035 - Calbiochem

234491
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Przegląd

Replacement Information

Tabela kluczowych gatunków

Empirical Formula
C₁₆H₁₄BrN₃O₂

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
234491-500UG
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      Ampulka plastikowa 500 μg
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      Description
      Catalogue Number234491
      Brand Family Calbiochem®
      References
      Product Information
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
      FormLiquid
      FormulationA 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490) in DMSO.
      Hill FormulaC₁₆H₁₄BrN₃O₂
      Chemical formulaC₁₆H₁₄BrN₃O₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>25 pM
      Primary Target K<sub>i</sub>6 pM against the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ PD 153035 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ PD 153035 - Calbiochem Certificates of Analysis

      TitleLot Number
      234491
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-June-2008 RFH
      DescriptionAn extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
      FormLiquid
      FormulationA 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆H₁₄BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Irritant