420133 JNK Inhibitor VI, TI-JIP153-163 - Calbiochem

420133
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Przegląd

Replacement Information

Tabela kluczowych gatunków

Empirical Formula
C₆₁H₁₀₄N₂₀O₁₄

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
420133-2MG
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      Ampulka plastikowa 2 mg
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      Description
      OverviewA murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134).
      Catalogue Number420133
      Brand Family Calbiochem®
      SynonymsTruncated Inhibitor based on JNK-Interacting Protein 1, H₂N-RPKRPTTLNLF-NH₂
      References
      ReferencesBarr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₁H₁₀₄N₂₀O₁₄
      Chemical formulaC₆₁H₁₀₄N₂₀O₁₄
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJNK
      Primary Target IC<sub>50</sub>KD in low µM range
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      JNK Inhibitor VI, TI-JIP153-163 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      JNK Inhibitor VI, TI-JIP153-163 - Calbiochem Certificates of Analysis

      TitleLot Number
      420133

      References

      Przegląd literatury
      Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-July-2008 RFH
      SynonymsTruncated Inhibitor based on JNK-Interacting Protein 1, H₂N-RPKRPTTLNLF-NH₂
      DescriptionA murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134).
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₁H₁₀₄N₂₀O₁₄
      Peptide SequenceH-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBarr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.