119113 Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem

119113
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Empirical FormulaCAS #
C₁₄H₁₁N₃O₂ 352341-26-5

Ceny i dostępność

Numer katalogowy DostępnośćOpakowanie Ilość/opak. Cena netto Ilość
119113-5MG
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      Butelka szklana 5 mg
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      Description
      OverviewA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
      Catalogue Number119113
      Brand Family Calbiochem®
      Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
      References
      ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
      Product Information
      CAS number352341-26-5
      DeclarationMarketed by Promega Corp. under the registered trademarks.
      FormOff-white solid
      Hill FormulaC₁₄H₁₁N₃O₂
      Chemical formulaC₁₄H₁₁N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      119113

      References

      Przegląd literatury
      Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
      DescriptionA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number352341-26-5
      Chemical formulaC₁₄H₁₁N₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.